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Their nanoscale size, high surface area-to-volume ratio, and ability to generate reactive oxygen species (ROS) make them highly effective against both Gram-positive and Gram-negative bacteria

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In tendon tissues, NADPH oxidases, particularly NOX1, NOX2, and NOX4, have emerged as key contributors to both physiological signaling and pathological oxidative stress in response to mechanical loading, inflammation, and metabolic dysregulation (Vermot et al., 2021